Application of myostatin in sheep breeding programs: A review

نویسندگان

  • Abdolreza Salehi Department of Animal and Poultry Science, College of Abouraihan, University of Tehran, Iran
  • Younes Miar Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
چکیده مقاله:

Myostatin or growth and differentiation factor 8 (GDF8), has been known as the factor causing double muscling phenotypes in which a series of mutations make the myostatin protein inactive, hence disabling it to regulate the deposition of muscle fibre. This phenotype happens with high frequency in a breed of sheep known as the Texel. Quantitative trait loci (QTL) studies show that a portion of the OAR2 that encompasses GDF8 has a major effect on muscular growth of Belgian Texel, on the muscling and fat depth in New Zealand Texel sires, and UK Texel and Charollais sheep. The functional polymorphism resides inside the GDF8 non-coding region. To date, there have been studies showing biallelic SNPs with significantly different allelic frequencies between hyper-muscled Texel and control animals including one in the 3'UTR  (g.+6223G>A) and one in 2.5 kb upstream from the GDF8 transcription start site (g.-2449G>C). The GDF8 allele of the Texel sheep is characterized by one G to A transition in the 3'UTR, creating a target site for mir1 and mir206 which are highly expressed in skeletal muscles. This prevents myostatin gene translation, thus contributing to the double muscling of Texel sheep. Therefore, the GDF8 g.+6223A allele seems to be a causative variable increasing muscularity in the Texel rams and could be identified as a quantitative trait nucleotide.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

application of myostatin in sheep breeding programs: a review

myostatin or growth and differentiation factor 8 (gdf8), has been known as the factor causing double muscling phenotypes in which a series of mutations make the myostatin protein inactive, hence disabling it to regulate the deposition of muscle fibre. this phenotype happens with high frequency in a breed of sheep known as the texel. quantitative trait loci (qtl) studies show that a portion of t...

متن کامل

Application of DNA Molecular Markers in Plant Breeding (Review article)

Plant Breeding has utilized a wide range of techniques and methods to improve the quality and quantity of plants. The molecular markers are the tools that have provided a new perspective for plant breeding advancements. This article has reviewed the various advantages and uses of molecular markers and the utilization of the high potential of natural polymorphisms within communities, combined wi...

متن کامل

Genomic application in sheep and goat breeding

Sheep and goat breeds are selected worldwide for meat, wool, and dairy production, and breeding objectives also include other functional traits such as reproductive performance and disease resistance. In early 2007, the development of next-generation sequencing (NGS) allowed de novo sequencing of sheep (Jiang et al., 2014) and goat genomes (Dong et al., 2013). In turn, it offered an opportunity...

متن کامل

The Expression of Myogenin and Myostatin Genes in Baluchi Sheep

Myogenin gene (MYoG) affects the synthesis of muscle myofibrillar growth and increase of meat production. The myostatin (MSTN) gene is identified as a specific negative regulator of skeletal muscle growth. Reduction of the expression level of MSTN throughmutation in the sequence of this gene leads to an increase of myogenesis and regeneration of muscle cells during the postnatal growing period ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 3  شماره 1

صفحات  33- 43

تاریخ انتشار 2014-03-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023